감초알카로이드에 관한 연구(제 4 보) -감초 알카로이드 분획의 항궤양작용에 대한 검토-

• 영문명: Studies on Alkaloid of Glycyrrhiza glabra L. IV. -Anti-ulcer Activity of Licorice Alkaloid Fraction-
• 발행기관: 대한약리학회
• 저자명: 홍사악(Hong, S.A.) 박찬웅(Park, C.W.) 조항영(Cho, H.Y.) 이철우(Lee, C.W.)
• 간행물 정보: 『대한약리학잡지』제5권 제2호, 149~152쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1969.12.31

영문 초록

Anti-ulcer activity of licorice alkaloid fraction, separated from Glycyrrhiza glabra L. by fractionation according to general alkaloid purification procedure, were studied with various experimental gastric ulcers. In Shay ulcer, licorice alkaloid fraction inhibit significantly response rate and severity of ulcer. But there was no significant changes in volume and pH of gastric contents. A male rat was fixed on a board and immersed up to breast in water of 25˚C for 20 hrs. Hemorrhage and erosion develop in all the animals on the mucosa of the glandular portion of stomach. Licorice alkaloid fraction (5 mg/kg, 10 mg/kg) inhibit significantly in the severity of stress ulcer but there was no changes in the response rate. Chlorpromazine produce marked inhibition in the severity and response rate of ulcer It was suggested that at least the anti-ulcer activity of licorice alkaloid fraction was not mediated by central depression.