Effects of Active Body Temperature Maintenance on Ketamine-Alfaxalone Anesthesia in Rats

• 발행기관: 한국동물보건학회
• 저자명: Jong-Min Kim
• 간행물 정보: 『한국동물보건학회지』4권 3호, 237~244쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2025.09.30

국문 초록

Hypothermia during rodent anesthesia can alter drug metabolism and recovery. This study examined the impact of body temperature maintenance with a warming pad on ketamine-alfaxalone anesthesia in rats. Sixteen male Lewis rats (8 weeks, 250-300 g) were assigned to four groups (n=4) based on ketamine dose (15 or 45 mg/kg, IP) with alfaxalone (3 mg/kg) and warming use. Induction time, analgesia, anesthesia duration, body temperature, heart rate, and respiratory rate were recorded. Warming significantly reduced analgesia and anesthesia durations at both ketamine doses compared with unwarmed rats, despite a threefold dose difference. Body temperature was maintained near 37 °C with warming but declined to ~34 °C without. Heart rate and respiratory rate decreased during anesthesia and normalized upon recovery. Warming pad use during ketamine-alfaxalone anesthesia prevented hypothermia and shortened anesthesia duration, supporting its routine application to enhance consistency and animal welfare.

목차

1. Introduction

2. Materials and methods

3. Results

4. Discussion

Acknowledgement

Orcid

References

키워드

ketamine alfaxalone hypothermia rodent anesthesia body temperature maintenance