인삼(人蔘) 각(各) Fraction이 Nembutal, Chlorpromazine 및 Reserpine 투여(投與)로 인(因)한 Mouse체온하강(體溫下降)에 미치는 영향(影響)

• 영문명: Influence of Each Fraction from Panax Ginseng on the Hypothermia in Mice Elicited by Reserpine, Nembutal and Chlorpromazine
• 발행기관: 대한약리학회
• 저자명: 홍사악(Hong, Sa-Ack) 조항영(Cho, Hang-Young) 홍순근(Hong, Soon-Keun)
• 간행물 정보: 『대한약리학잡지』제5권 제2호, 93~104쪽, 전체 12쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1969.12.31

영문 초록

Saponin, essential oil, fat oil and alkaloidal fraction were fractionated from the ethanol extract of fanax ginseng. Effect of each fraction of Panax ginseng upon the temperature response induced by reserpine, chlorpromazine and nembutal was investigated in mice, so as to secure some hidden facets of each fraction of Panax ginseng acting upon central nervous system. The authors could arrive at some results, that is: (1) Inhibitory effect of Panax ginseng upon temperature decline induced by nembutal and chlorpromazine and potentiating action upon hyperthermia induced by reserpine reside mainly in saponin fraction and slightly in essential oil fraction. (2) The effect of Ginseng saponin on temperature response in nice seems to be related with the liberation of serotonin and histamine.