볼낙(Sebastes inermis) 방광(膀胱)의 Adrenotropic Receptor에 관(關)한 연구(硏究)

• 영문명: Studies on the Adrenotropic Receptors of the Isolated Urinary Bladder from Sebastes Inermis
• 발행기관: 대한약리학회
• 저자명: 손용석(Sohn, Yong-Seuk) 홍기환(Hong, Ki-Whan) 박중양(Park, Jung-Yang)
• 간행물 정보: 『대한약리학잡지』제5권 제2호, 115~120쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1969.12.31

영문 초록

The authors studied the adrenotropic receptors of isolated urinary bladder from Sebastes inermis, using adrenergic activators such as epinephrine, nor-epinephrine, isoproterenol and phenylephrine and adrenergic blocking agents such as phenoxybenzamine, pronethalol and propranolol. The studies have revealed the following results. 1) The spontaneous motility of isolated bladder from Sebastes inermis was inhibited by epinephrine nor-epinephrine, isoproterenol and phenylephrine. 2) The inhibitory effect of phenylephrine on the Sebastes inermis bladder was blocked by phenoxybensamine. 3) The inhibitory effect of isoproterenol was blocked by pronethalol and propranolol. 4) The effect of epinephrine and nor-epinephrine on the Sebastes inermis bladder was usually not blocked by either kind of blocking agent alone, but was blocked by a combination of α and β blockades. 5) It is, therefore, concluded that the Sebastes inermis bladder has alpha and that both receptors, and that both receptors subserve retaxation or inhibition.