Dothiepin의 항우울 효과에 대한 임상연구

• 영문명: A Clinical Study o f Antidepressant Effect of Dothiepin
• 발행기관: 대한신경정신의학회
• 저자명: 이철 이규환 채영래 백인호
• 간행물 정보: 『신경정신의학』제29권 제5호, 1017~1021쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1990.09.30

영문 초록

This study was designed to investigate the therapeutic efficacy and adverse reactions of dothiepin. The subjects consisted of 40 patients diagnosed as major depression with DSMIII- R, who had been admitted to the Department of Neuropsychiatry, Kangnam St. Mary’ s Hospital, Catholic University Medical College from October 1，1989 to May 31，1990. Under double-blind conditions they were treated with either dothiepin or mianserin for a period of 4 weeks. Patients were assessed by Hamilton Depression Scale before treatment and after 1，2 and 4 weeks of treatment. The results were as follows • 1) A statistically significant improvement on the Hamilton Depression Scale was seen with both drugs after only one week’ s treatment(P〈0.001). 2) A comparison of the antidepressant effects of both drugs failed to show a statistical difference. 3) As for the side effects associated with dothiepin, constipation was the commonest, followed by dry mouth, urinary retention, and drowsiness. However, the anticholinergic effects of dothiepin were mild, and by indirect comparison, dothiepin seemed to have fewer side effects than amitriptyline. In view of our results, dothiepin was found to be an effective antidepressant agent

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