알코올 일과성 기억상실 블랙아웃과 알코올 관련 신경인지장애

• 영문명: Alcohol induced transient memory loss blackout and alcohol-related neurocognitive disorder
• 발행기관: 한국중독정신의학회
• 저자명: 김양식(Yangsik Kim) 배재남(Jae Nam Bae)
• 간행물 정보: 『중독정신의학』Vol.29, No.2, 48~51쪽, 전체 4쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2025.09.30

국문 초록

Alcohol, characterized by both polar and non-polar properties, is a Group 1 carcinogen capable of freely crossing cellular membranes, including the blood-brain barrier. Through its intrinsic cytotoxicity and the genotoxic effects of its primary metabolite, acetaldehyde, alcohol exerts widespread impact on the nervous system and cognitive function. Given the growing elderly population and the sociocultural permissiveness toward alcohol use, a critical review of alcohol’s role in major neurocognitive disorders (NCD, also known as dementia) is warranted. This review focuses on the relationship between alcohol-induced transient memory impairment (i.e., blackouts) and major NCDs. Meta-analyses suggest that experiencing blackouts is associated with an increased prevalence of major NCD, underscoring the clinical importance of distinguishing alcohol-related dementia and Wernicke-Korsakoff syndrome. Furthermore, high-risk drinking is increasingly recognized as a significant risk factor for cognitive decline and early-onset NCM, while recent evidence challenges the previously held notion of a protective effect of light-to-moderate alcohol consumption. Based on these findings, alcohol should be considered a modifiable risk factor for major NCD, and public health interventions aimed at reducing alcohol consumption and enhancing societal awareness are urgently needed.

목차

서 론

블랙아웃과 주요 신경인지장애의 연관성

베르니케-코르사코프(Wernicke-Korsakoff) 증후군과 일차 알코올 치매

주요 인지기능장애에서 알코올 사용장애 동반 및 알코올의 영향

결 론

REFERENCES

키워드

알코올 블랙아웃 신경인지장애 치매 일과성 기억 상실 alcohol blackout neurocognitive disorder dementia transient memory loss