영지로부터 추출한 다당체의 실험적 간경화에 대한 섬유화 억제효과

• 영문명: The Antifibrotic Effects of Polysaccharides Extracted from Garnoderma lucidum on the Experimental Hepatic Cirrhosis
• 발행기관: 대한약학회
• 저자명: 박은전(Eun Jeon Park) 김기영(Ki Young Kim) 김재백(Jae Baek Kim) 김수웅(Soo Woong Kim) 이승용(Seung Yong Lee) 손동환(Dong Hwan Sohn)
• 간행물 정보: 『약학회지』제38권 제3호 (1994년), 338~344쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.06.30

영문 초록

This study was carried out to investigate the antifibrotic effects of polysaccharides extracted from Garnoderma lucidum. The biliary cirrhosis was induced by bile duct ligation/scission(BDL/S) in rats. BDL/S rats were dosed 5 mg/rat/day orally for 4 weeks after the operation. Antifibrotic effects were evaluated by serum biochemical values, serum procollagen type III peptide(PIIINP) levels, liver hydroxyproline contents, and light microscopical histology. The results obtained were as follows; 1) PIIINP levels in sera of treated BDL/S group were lowered to 50% of those of untreated BDL/S group. 2) Hydroxyproline contents in the liver of treated BDL/S group were also reduced to 83% of those of untreated BDL/S rats. 3) The hepatic damage such as hepatocellular necrosis, inflammation, bile duct proliferation and fibrosis was less severe in the livers of treated rats. These results suggest polysaccharides extracted from Garnoderma lucidum to be a promising agent for the inhibition of hepatic cirrhosis(fibrosis).

키워드

Biliary cirrhosis Garnoderma lucidum N-terminal procollagen type III peptide.