우르소데옥시콜린산 및 케노데옥시콜린산의 베타시클로덱스트린 포접복합체의 물리화학적 특성비교

• 영문명: Comparison of Physicochemical Properties between Ursodeoxycholic Acid and Chenodeoxycholic Acid Inclusion Complexes with beta-Cyclodextrin
• 발행기관: 대한약학회
• 저자명: 이승용(Seung Yong Lee) 정연복(Youn Bok Chung) 한건(Kun Han) 신재영(Jae Young Shin)
• 간행물 정보: 『약학회지』제38권 제3호 (1994년), 300~310쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.06.30

영문 초록

Physicochemical properties for the inclusion complex of chenodeoxycholic acid(CDCA) and it''s 7beta-hydroxy epimer ursodeoxycholic acid(UDCA) with beta-cyclodextrin(beta-CyD) were studied. The formation of the complex in the solid state were confimed by polarized microscopy and differential scanning calorimetry(DSC). Proton nuclear magnetic resonance(1H-NMR)spectroscopy showed that CDCA and UDCA form an inclusion complex with beta-CyD in aqueous solution. The 1 : 1 stoichiometry of the complex was dextermined by the continuous variation method. From DSC and 1H-NMR studies, there were not any differences between CDCA and UDCA. Complex of CDCA and UDCA showed increase in solubility and dissolution compared with CDCA and UDCA alone, respectively. Solubility pattern of UDCA complex was pH independent but, CDCA complex was like that of CDCA. Dissolution rate increased markedly in case of UDCA complex compared with CDCA complex, especially in acidic pH value.

키워드

ursodexycholic acid chenodeoxycholic add beta-cyclodextrin inclusion complex polarized microscopy differential scanning calorimetry nuclear magnetic resonance spectroscopy solubility dissolution rate.