Drosophila에서 인삼 및 단삼 추출물이 MNNG의 돌연변이원성에 미치는 영향

• 영문명: Effects of Ginseng and Salvia miltiorrhiza Extracts on the Mutagenicity of MNNG in Drosophila
• 발행기관: 대한약학회
• 저자명: 최영현(Yung Hyun Choi) 정해영(Hae Young Chung) 유미애(Mi Ae Yoo) 이원호(Won Ho Lee)
• 간행물 정보: 『약학회지』제38권 제3호 (1994년), 332~337쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.06.30

영문 초록

Using germinal and somatic cell mutation assaying systems of Drosophila melanogaster, effects of Ginseng and Salvia miltiorrhiza extracts on the in vivo mutagenicity induced by N-methyl-N''-nitro-N-nitrosoguanidine(MNNG) were investigated. For these purpose, the attached-X method and the mwh/flr spot test system which are an X-linked lethal mutation and a somatic chromosome mutation assaying system, respectively, were used. In the induction of X-linked lethal mutations during the spermatogenesis, MNNG showed more actions in the sperm and spermatid stages, in which Ginseng and Salvia miltiorrhiza extracts had remarkable inhibitory effects than other stages. Ginseng and Salvia miltiorrhiza extracts reduced the mutagenicity by MNNG in the mwh/flr system, which reveal that they can inhibit gene mutation, deletion and mitotic chromosomal recombination. These results seem to suggest that Ginseng and Salvia miltiorrhiza extracts may exert their inhibitory effects to in vivo mutagenic and/or carcinogenic properties of DNA-damaging agents.

키워드

Ginseng and Salvia miltiorrhiza extracts mutagenicity MNNG Drosophila.