새로운 베타락탐계 항생물질 합성과 항균활성

• 영문명: Studies on Synthesis and Antimicrobial Activity of New beta-Lactam Antibiotics
• 발행기관: 대한약학회
• 저자명: 고옥헌(Ok Hyun Ko) 홍석순(Sun Soon Hong) 하재천(Jae Chun Ha) 김영수(Young Soo Kim)
• 간행물 정보: 『약학회지』제38권 제3호 (1994년), 322~331쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1994.06.30

영문 초록

For the development new cephalosporin antibiotics with aminothiazolmethoxyimino moiety in the C-7 position and triazolthiomethyl moiety in the C-3 position of cephem ring, 7beta-[(z)-2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[5-(aryl or het.)-4-phenyl-4H-1,2,4-triazol-3-yl]thiomethyl-3-cephem-4-carboxylic acids were synthesized. These compounds were tested for antimicrobial activitiy in vitro against ten species of microorganisms. It showed remarkable antibacterial activity against Bacillus subtilis ATCC 6633, Micrococcus luteus ATCC 9341 and Escherichia coli ESS. The antibacterial activity of most new compounds showed more active than cefazoline, but these compounds were lower active than cefotaxime against Pseudomonas aeruginosa IFO 13130