토끼에서 아세트아미노펜 연질캅셀제의 생체이용율에 미치는 제제처방들의 영향

• 영문명: Effects of Various Formulations on Bioavailability of Acetaminophen Soft Gelation Capsules in Rabbits
• 발행기관: 대한약학회
• 저자명: 박기배(Gee Bae Park) 이용석(Yong Suk Lee) 최명호(Myung Ho Choi) 이도익(Do Ik Lee) 이광표(Kwang Pyo Lee)
• 간행물 정보: 『약학회지』제36권 제6호 (1992년), 598~603쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.12.29

영문 초록

The purpose of this study was to assess the effect of three formulations; product A (polyethylene glycol was used as a main dispersing agent), product B (wax mixture was used as a main dispersing agent) and product C((silicon dioxide was used as a main dispersing agent) on bioavailability of acetaminophen soft gelatin capsules(softgels) and to develop an effective acetaminophen softgel which exhibits an excellent bioavailability. Acetaminophen softgels of various formulations were prepared as 4 minim round type by rotary die method. Four softgels of the three formulation (A, B, C), each of which contained 50 mg acetaminophen, were administered orally to 12 normal healthy rabbits using a three-way cross over design. Plasma acetaminophen concentrations were measured by HPLC. The results obtained in this study were as follows: 1. The Tmax rank order of acetaminophen softgel was C(63.75 +/- 10.62 min) > A(36.25 +/- 5.37 min) > B(35 +/- 6.74 min). 2. The decreasing Cmax order of softgel product was A(93,51 +/- 0.55 mcg/ml) > B(3.16 +/- 0.37 mcg/ml) > C(2.6 +/- 0.55 mcg/ml). 3.The [AUC]0infinite rank order for three acetaminophen softgel formulations was A (14.89 +/- 1.56mcg/ml.min) > B(14.39 +/- 1.43 mcg/ml.min) > C(11.45 +/- 1.49mcg/ml.min). 4. Pharmacokinetic parameters such as Tmax, Cmax and [AUC]0infinite of product A and B did not differ significantly(p>0.05). On the other hand, those of product C were significantly different(p>0.05).

키워드

Acetaminophen soft gelatin capsule formulation bioavailability.