생체시료로부터 미량 이부푸로펜의 고상추출에 사용될 흡착제들의 특성

• 영문명: Characterization of Adsorbents for the Solid-Phase Extraction of Trace Ibuprofen from Biological Samples
• 발행기관: 대한약학회
• 저자명: 김경례(Kyoung Rae Kim) 심원희(Weon Hee Shim)
• 간행물 정보: 『약학회지』제36권 제6호 (1992년), 563~569쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.12.29

영문 초록

The sorption and desorption properties of four different solid adsorbents were evaluated for the trace enrichment of ibuprofen from biological samples. Chromosorb 107 gave the highest dynamic adsorption coefficient. Among the organic solvents examined, acetone gave the highest desorption coefficient. Using the Chromosorb 107 column, the optimum elution volume of the eluting solvent was evaluated from the breakthrough curve of ibuprofen. The usefulness of Chromosorb 107 as the solid adsorbent and acetone as the eluting solvent was examined for the solidphase extraction of ibuprofen from serum in the concentration range of 20~40mcg/ml.

키워드

Solid-phase extraction ibuprofen Chromosorb 107 adsorption coefficient.