노르후록사신-금속이온 착물의 물리화학적 성질 및 항균력

• 영문명: Physiochemicl Properties and Antibacterial Activities of Metal Complexes of Norfloxacin
• 발행기관: 대한약학회
• 저자명: 박원봉(Won Bong Park) 김경아(Kyung Ah Kim) 이명환(Myung Hwan Lee) 이동선(Dong Sun Lee) 노동윤(Dong Yoon Rho)
• 간행물 정보: 『약학회지』제36권 제6호 (1992년), 577~581쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.12.29

영문 초록

Norfloxacin complexes of Fe2+, Cu2+ and Al3+ have been prepared as solids. The stoichiometry of the complexes has been established. IR investigation indicates the metal-ligating sites in norfloxacin. The bioactivities of complexes all lower than that of norfloxacin. The solubilities and partition coefficients have been measured as a function of temperature. The data are used to evaluate the thermodynamic parameters deltaG, deltaH, deltaS for the solute transfer process and compared with the parent quinolone, norfloxacin. The existence of such complexes is discussed in the light of quinolone mode-of-action theories.

키워드

Norfloxacin complex physicochemical properties mode-of-action.