효소함유 정제에 있어서 붕해제의 효과에 미치는 부형제의 영향

• 영문명: Effect of Diluents on Disintegration Efficiency of Disintegrants in Enzyme Tablets
• 발행기관: 대한약학회
• 저자명: 김정훈(Jeong Hoon Kim) 김승환(Seung Hwan Kim) 차봉진(Bong Jin Cha) 권종원(Jong Won Kwon)
• 간행물 정보: 『약학회지』제36권 제6호 (1992년), 513~517쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.12.29

영문 초록

The effect of solubility and hygroscopicity of some tablet diluents on the disintegration of enzyme tablets was investigated. Tablets were prepared by direct compression method using sodium starch glycolate, crospovidone, croscarmellose sodium and low-substituted hydroxypropyl cellulose as super disintegrants. Lactose, dextrose, sucrose, sorbitol and calcium phosphate dibasic were selected as typical diluents in this study. They were different in solubility (sucrose, sorbitol > dextrose > lactose > calcium phosphate dibasic) and hygroscopicity (sorbitol>sucrose>dextrose > caicium phosphate dibasic, lactose). The disintegrants accelerated differently the disintegration of the tablets prepared with different diluents in the decreasing order of calcium phosphate dibasic > lactose > dextrose > sucrose and sorbitol. These results indicate highly soluble and/or hygroscopic diluents decrease the efficiencies of super disintegrants in the enzyme tablets.

키워드

Enzyme tablet disintegration disintegrants super disintegrants diluents.