질산비스마스의 겐타마이신 신독성 경감기전

• 영문명: Protective Mechanism of Bismuth Nitrate Against Gentamicin Nephrotoxicity
• 발행기관: 대한약학회
• 저자명: 김정선(Jung Sun Kim) 정해영(Hae Young Chung) 노영재(Young Jae Rho) 이상록(Sang Rok Lee)
• 간행물 정보: 『약학회지』제36권 제6호 (1992년), 570~576쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.12.29

영문 초록

The treatment with gentamicin in the presence of pretreatment with bismuth nitrate significantly reduced blood urea nitrogen compared with given gentamicin alone. But the amelioration of gentamicin-induced nephrotoxicity by bismuth nitrate was abolished by pretreatment with indomethacin that is cyclooxygenase inhibitor, which significantly decreased renal glutathione S-transferase activity and thiobarbituric acid reactive substance compared with mice of given gentamicin and bismuth nitrate. On the other hand, treatment with bismuth nitrate significantly increased prostaglandin E2 production in rat kidney slice. These results suggest that bismuth nitrate might ameliorate the nephrotoxicity of gentamicin via prostaglandin E2 production.

키워드

Gentamicin bismuth nitrate nephrotoxicity cyclooxygenase inhibitor prostaglandin E2 .