생쥐에서 종양세포의 암유전자발현에 대한 울솔산의 효과

• 영문명: Effects of Ursolic Acid on Oncogene Expression Detected by In Situ Hybridization in Mice
• 발행기관: 대한약학회
• 저자명: 류태형(Tae Hyong Rhew) 박성미(Sung Mi Park) 박건영(Kun Young Park) 정해영(Hae Young Chung) 하재청(Jae Chung Hah) 이정규(Chung Kyu Lee)
• 간행물 정보: 『약학회지』제36권 제6호 (1992년), 529~537쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.12.29

영문 초록

To investigate the effect of ursolic acid on the expression of oncogenes in tumor cells of mice, sarcoma 180 ascites tumor cells were implanted into the left groin of ICR mice and the tumor bearing mice were treated with ursolic acid. The expression of oncogenes were measured by in situ hybridization method. Ursolic acid significantly reduced the expression of oncogenes in the tumor cells. Therefore, it can be said that the prestated anticarcinogenic effect of ursolic acid could be partly ascribed to the mechanism included in the oncogene''s transcription level.

키워드

Ursolic acid oncogene in situ hybridization c-myc c-fos Ha-ras.