Phenylethanolamine N-methyltransferase: 부신, 뇌간, 시상하부 효소의 조절

• 영문명: Phenylethanolamine N-methyltransferase: Regulation of the Enzyme in Adrenal Gland, Brain Stem and Hypothalamus
• 발행기관: 대한약리학회
• 저자명: 전양숙(Yang-Sook Chun) 서유헌(Yoo-Hun Suh)
• 간행물 정보: 『대한약리학잡지』제32권 제2호, 159~168쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1996.09.30

영문 초록

To determine the regulatory mechanism of phenylethanolamine N-methyltransferase (PNMT) in the adrenal gland and in central nervous system, we observed the change of enzyme activity and mRNA level of PNMT in the adrenal gland, the brain stem, and hypothalamus of rats, which were injected with two neuroleptic agents(reserpine and haloperidol ). Reserpine depleting catecholamines in presynaptic vesicle increased PNMT activities in the adrenal gland and the brain stem to 150% of the control in time-dependent manner, but not in the hypothalamus. Haloperidol blocking dopamine receptor decreased PNMT activities in the adrenal gland and the hypothalamus, but not in the brain stem. Thus, the results indicate that catecholamines inhibit synthesis of epinephrine in the brain stem and the adrenal gland, and that dopamine stimulates synthesis of epinephrine in the hypothalamus and the adrenal gland. In addition, since the change of mRNA levels were nearly in accordance with the change of activities, the transcriptional regulation of PNMT is considered the mechanism of the regulation of epinephrine neuron.

키워드

Phenylethanolamine N-methyltransferase Adrenal gland Brain stem Hypothalamus