Lithium 및 Carbamazepine 이 Apomorphine으로 유도된 일측 흑질체 파괴 백서의 회전운동에 미치는 영향

• 영문명: Influence of Lithium and Carbamazepine on the Turning Behavior Induced by Apomorphine in the Substantia Nigra-Lesioned Rat
• 발행기관: 대한신경정신의학회
• 저자명: 손희섭 유상은 은홍배
• 간행물 정보: 『신경정신의학』제34권 제2호, 564~572쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1995.03.30

영문 초록

This study was designed to evaluate the effects of haloperidol, lithium and carbamazepine on the apom orphine-induced turning behavior in the substantia nigra-lesioned rats with 6-hydroxydopamine (6-O H D A ). All rats were administered Swig of 6-hydroxydopamine into the Rt substantia nigra and were divided into seven groups. Each group was composed of six rats and was administered apom orphine, haloperidol(0.03mg/kg, 0.3mg/kg), lithium(2mg/kg, 20mg/kg) and carbam azepine(2 mg/kg, 20mg/kg) respectively once a week for 7 weeks. The authors examined the effects of haloperidol, lithium and carbam azepine on the apom orphine- induced turning behavior. The results were as follows : 1) Haloperidol inhibited the turning behavior response induced by apom orphine significantly. 2) Lithium inhibited the turning behavior response induced by apom orphine significantly. 3) Carbam azepine did not influence the turning behavior response induced by apomorphine. From the above results, it is suggested that haloperidol and lithium inhibits the dopaminergic activity, but carbamazepine dose not influence on the dopaminergic activity.

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키워드

Substantia nigra-lesion Apomorphine Turning behavior Haloperidol Lithium Carbamazepine