만성 정신분열증환자의 보체성분 C4A 그리고 C4B의 이인자형 빈도에 관한 연구

• 영문명: A Study on the Complement Component C4A and C4B Allotype Frequencies in Chronic Schizophrenic Patients
• 발행기관: 대한신경정신의학회
• 저자명: 정주화 정해익 정태호
• 간행물 정보: 『신경정신의학』제34권 제2호, 435~442쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1995.03.30

영문 초록

This study was carried out to see if there were any peculiar pheno{ypes o f complement C4A and C4B distribution in patients with chronic schizophrenia. Allotypes were analyzed by electrophoretic separation on agarose gel and then identified by immunofixation technique. The diagnosis of schizophrenia was made according to DSM-HI-R. The schizophrenic patients consisted of 13 paranoid, 14 undifferentiated and 4 disorganized types. The C4 allotype frequencies of these subjects were com pared with the 160 healthy controls. The results were as follows : 1) C4A6 antigen frequency was significantly increased in all schizophrenics com pared to the control group. 2) C4A4 antigen frequency was significantly increased in paranoid type schizophrenic patients com pared to the control group. 3) C4A6 antigen frequency was significantly increased in undifferentiated type schizophrenic patients com pared to the control group. 4) C4A6 antigen frequency was significantly increased in schizophrenic patients with family histoiy com pared to the control group. This leads C4A6 and C4A4 to be indicative of the possibility of a biological or a genetic marker. A further study, however, is required on a large basis of subjects.

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Chronic schizophrenia Complement Genetic marker