정신분열증 환자에서 Sertraline의 병합투여가 혈장 Haloperidol 농도에 미치는 효과

• 영문명: The Effects of Sertraline on Plasma Haloperidol Concentrations in Schizophrenics
• 발행기관: 대한신경정신의학회
• 저자명: 유영운 김승현 이민수
• 간행물 정보: 『신경정신의학』제34권 제2호, 544~552쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1995.03.30

영문 초록

Objects Along with the increased interest in selective serotonin reuptake inhibitors recently, m any researches have undertaken to observe interactions with different drugs. In cases where schizophrenics with depressive or obsessive symptoms were shown and o f negative symptom schizophrenics, when selective serotonin reuptake inhibitor was administered together with antipsychotics, meaningful result was observed. Our research is to find out what would change to the concentration of plasm a haloperidol when sertraline is administered to patients who already are being treated with haloperidol. Method : Sixteen patients who are being treated with same dosage of haloperidol for at least 2weeks and did not respond to traditional antipsychotics, were administered with 50mg of sertraline for period of 2 weeks. Then, with the use of a H PLC equipped with UVdetector, the concentration changes between plasma haloperidol and the reduced haloperidol were observed. Result: The changes in the concentration o f haloperidol was from 8.52± 4.22ng/ml to 10.91 ± 5. 38ng/ml, so there was a significant increase(p

목차

서 론

연구대상 및 방법

결 과

고 찰

결 론

참 고 문 헌

키워드

Sertraline Haloperidol Reduced haloperidol

참고문헌