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학술논문

Unraveling Anabolic Resistance in Sarcopenia: A Narrative Synthesis of Age-Related Impairments in Muscle Protein Synthesis

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영문명
발행기관
대한운동학회
저자명
Hyun Joo Kang
간행물 정보
『아시아 운동학 학술지』제27권 제3호, 107~113쪽, 전체 7쪽
주제분류
예술체육 > 체육
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발행일자
2025.07.31
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OBJECTIVES Anabolic resistance, characterized by the diminished muscle protein synthesis (MPS) response to anabolic stimuli, represents the fundamental pathophysiological mechanism underlying age-related sarcopenia. This condition has a significant impact on clinical outcomes, including increased healthcare costs, disability, and mortality. To synthesize current clinical evidence on anabolic resistance mechanisms and evaluate evidence-based therapeutic interventions for its mitigation. METHODS This narrative synthesis was conducted by reviewing peer-reviewed clinical and translational studies published between January 2010 and March 2025. A structured search was performed in PubMed and Scopus using combinations of the keywords: “anabolic resistance”, “muscle protein synthesis”, “sarcopenia”, “resistance training”, “aging”, and “protein intake”. RESULTS Anabolic resistance manifests as an elevated protein threshold requirement (0.40 g/kg/day per meal vs. 0.24 g/kg/day in young adults) and reduced exercise-induced MPS stimulation. Physical inactivity amplifies this resistance through a feed-forward mechanism. Clinical evidence demonstrates that resistance training acts as the primary intervention to restore anabolic sensitivity, with effects lasting 24-48 hours post-exercise. Optimal protein distribution (1.2-1.6 g/kg/day divided into 0.4 g/kg/day per meal) is essential to overcome the elevated anabolic threshold. Creatine monohydrate supplementation provides additional benefits when combined with resistance training. CONCLUSIONS Anabolic resistance represents a modifiable clinical target. Evidence-based interventions combining resistance training with optimized protein nutrition can effectively restore anabolic sensitivity and prevent sarcopenia progression. Future research should focus on personalized approaches and long-term clinical outcomes.

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APA

Hyun Joo Kang. (2025).Unraveling Anabolic Resistance in Sarcopenia: A Narrative Synthesis of Age-Related Impairments in Muscle Protein Synthesis. 아시아 운동학 학술지, 27 (3), 107-113

MLA

Hyun Joo Kang. "Unraveling Anabolic Resistance in Sarcopenia: A Narrative Synthesis of Age-Related Impairments in Muscle Protein Synthesis." 아시아 운동학 학술지, 27.3(2025): 107-113

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