Unraveling Anabolic Resistance in Sarcopenia: A Narrative Synthesis of Age-Related Impairments in Muscle Protein Synthesis

• 발행기관: 대한운동학회
• 저자명: Hyun Joo Kang
• 간행물 정보: 『아시아 운동학 학술지』제27권 제3호, 107~113쪽, 전체 7쪽
• 주제분류: 예술체육 > 체육
• 파일형태: PDF
• 발행일자: 2025.07.31

국문 초록

OBJECTIVES Anabolic resistance, characterized by the diminished muscle protein synthesis (MPS) response to anabolic stimuli, represents the fundamental pathophysiological mechanism underlying age-related sarcopenia. This condition has a significant impact on clinical outcomes, including increased healthcare costs, disability, and mortality. To synthesize current clinical evidence on anabolic resistance mechanisms and evaluate evidence-based therapeutic interventions for its mitigation. METHODS This narrative synthesis was conducted by reviewing peer-reviewed clinical and translational studies published between January 2010 and March 2025. A structured search was performed in PubMed and Scopus using combinations of the keywords: “anabolic resistance”, “muscle protein synthesis”, “sarcopenia”, “resistance training”, “aging”, and “protein intake”. RESULTS Anabolic resistance manifests as an elevated protein threshold requirement (0.40 g/kg/day per meal vs. 0.24 g/kg/day in young adults) and reduced exercise-induced MPS stimulation. Physical inactivity amplifies this resistance through a feed-forward mechanism. Clinical evidence demonstrates that resistance training acts as the primary intervention to restore anabolic sensitivity, with effects lasting 24-48 hours post-exercise. Optimal protein distribution (1.2-1.6 g/kg/day divided into 0.4 g/kg/day per meal) is essential to overcome the elevated anabolic threshold. Creatine monohydrate supplementation provides additional benefits when combined with resistance training. CONCLUSIONS Anabolic resistance represents a modifiable clinical target. Evidence-based interventions combining resistance training with optimized protein nutrition can effectively restore anabolic sensitivity and prevent sarcopenia progression. Future research should focus on personalized approaches and long-term clinical outcomes.

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키워드

Aging Anabolic Resistance Muscle Protein Synthesis Protein Nutrition Resistance Training Sarcopenia