Biological Effects of Vinca minor extract;

• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: Jun-Sub Kim Il-Hwan Yu Ji-Hye Joo Gyeong Hoe Nam Kyung-Hwan Jung Young Soo Chung Hyang-Yeol Lee
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제33권 제4호, 788~794쪽, 전체 7쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2016.12.30

영문 초록

Vinca alkaloids from plant Vinca minor have been investigated for their effects of tyrosinase inhibition, stimulation of ROS generation and increasement of cell migration activity. The methanolic crude extract and the water-soluble fraction exhibited IC50 value of 3.1 mg/mL and 2.1 mg/mL. Vinca minor extract treatment significantly increased ROS levels in HaCaT cells, in a concentration-dependent manner. Treatments of Vinca minor extract led to increase wound closure when compared with non-treatment. Low dose (0.1% or 0.3%) of extracts have not significantly affected, compared with that in controls. By contrast, 0.5% extract have dramatic effect on wound healing activity of keratinocytes. Effects of Vinca minor extract in a filter-based cell mobility assay appear similar to that of wound closure assay, which suggests that the Vinca minor extract have wound healing effects on skin.

목차

1. Introduction

2. Materials and Method

3. Results and Discussion

4. conclusion

References

키워드

Vinca minor extract Vincamine Tyrosinase inhibition ROS generation Wound Healing