Tissue Inhibitor of Metalloproteinases-2와 Endostatin의 혈관신생 제어 효능 평가

• 영문명: Efficacy Evaluation of Tissue Inhibitor of Metalloproteinases-2 and Endostatin on Angiogenesis
• 발행기관: 대한약학회
• 저자명: 김수현(Soo Hyeon Kim) 조영락(Young-Rak Cho) 윤현재(Hyun Jae Yoon) 고희영(Hee-Young Ko) 김평현(Pyeung-Hyeun Kim) 서동완(Dong-Wan Seo)
• 간행물 정보: 『약학회지』제54권 제6호 (2010년), 488~493쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.12.31

영문 초록

Therapeutic manipulation of angiogenesis, the formation of new vascular sprouts from existing capillaries, is one of the promising strategies for treatment of human diseases such as cancer, arthritis, and cardiovascular disorder. In the present study, we examined the effects and molecular mechanism of tissue inhibitor of metalloproteinases-2 (TIMP-2) and endostatin on fibroblast growth factor-2 (FGF-2)-stimulated endothelial cell proliferation, migration and adhesion in vitro, and angiogenesis in vivo. TIMP-2 and endostatin showed potent anti-angiogenic activity in vitro and in vivo. These effects appear to be mediated through different angiogenic signaling pathways. Collectively, our findings demonstrate that TIMP-2 and endostatin strongly inhibit FGF-2-induced angiogenic responses, and the establishment of fast and reproducible evaluation system in vitro and in vivo for the development of anti-angiogenic biomaterials and therapeutics.

키워드

TIMP-2 endostatin angiogenesis efficacy evaluation