L-형 칼슘 이온통로에 의한 파골세포 분화의 조절

• 영문명: The Regulation of Osteoclastogenesis by L-Type Channel Agonist
• 발행기관: 대한약학회
• 저자명: 노아롱새미(A Long Saemi Noh) 임미정(Mijung Yim)
• 간행물 정보: 『약학회지』제54권 제6호 (2010년), 461~465쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.12.31

영문 초록

We investigated the role of L-type Ca2+ channel in receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast formation. BayK 8644, a L-type Ca2+ channel agonist, was shown to increase the RANKLinduced osteoclastogenesis and actin ring formation in mouse bone marrow-dereived macrophage (BMM) culture system. BayK 8644 stimulated RANKL-induced extracellular signal-regulated kinase (ERK) and p38 MAP kinase (MAPK) activation, which leads to increased nuclear factor of activated T cells (NFAT)c1 expression. Taken together, these data indicate that L-type Ca2+ channel regulates osteoclast formation possibly through ERK- and p38-mediated NFATc1 expression.

키워드

L-type Ca2+ channel osteoclast NFATcl ERK p38