Galangin 및 양강추출물의 KBrO3 유도 DNA 및 염색체 손상에 대한 보호효과

• 영문명: Protective Effect of the 70% Ethanolic Extract of Alpinia officinarum and Galangin Against KBrO3-induced DNA and Chromosomal Damage in Mice
• 발행기관: 대한약학회
• 저자명: 양혜은(Hye Eun Yang) 허문영(Moon Young Heo)
• 간행물 정보: 『약학회지』제54권 제6호 (2010년), 423~428쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.12.31

영문 초록

The aim of this study was to evaluate the in vivo effect of galangin and the 70% ethanolic extract of Alpinia officinarum (AO) toward KBrO3-induced DNA and chromosomal damage in mice. Galangin and AO inhibited the formation of 8-hydroxy-2'-deoxyguanosine (8-OH2'dG) as an indicator of DNA oxidative damage in the liver cell. Galangin and AO showed the inhibitory effect on the formation of DNA single strand break in the splenocyte by single cell gel electrophoresis (SCGE) assay and also inhibited micronucleated reticulocyte (MNRET) formation of peripheral blood in tail blood of mice. Vit-E revealed antigenotoxic effects in DNA and chromosome levels, but galangin was more potent active compound compare to vit-E under our experimental conditions. The results suggest that the extract of Alpinia officinarum containing galangin can modify the oxidative DNA and chromosomal damage and may act as chemopreventive agent against oxidative stress in vivo.

키워드

galangin vit-E Alpinia officinarum potassium bromate 8-hydroxy-2'-deoxyguanosine oxidative DNA and chromosomal damage antigenotoxic effect