피페라진계 항히스타민제들의 브라디키닌 길항작용

• 영문명: Bradykinin Antagonistic Activities of Antihistamine Agents Containing Piperazine Moiety
• 발행기관: 대한약학회
• 저자명: 정성현(Sung Hyun Chung) 이소영(So Young Lee) 윤혜숙(Hye Sook Yun-Choi)
• 간행물 정보: 『약학회지』제37권 제6호 (1993년), 625~630쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.12.30

영문 초록

Among the six antihistamine agents tested in this study, homochlorcyclizine showed the highest bradykinin antagonistic activity in the receptor binding assay as well as the isolated rat ileum assay. Schild plot analysis of bradykinin-induced ileal contraction in the presence of three different concentrations of homochlorcyclizine revealed a pA2=6.26, and a correlation coefficient of 0.984. Homochlorcyclizine of (lOOmcM final concentration) also showed 25% antagonistic activity in the receptor binding assay.

키워드

Antihistamine agents bradykinin receptor binding assay Schild plot.