팔라듐 촉매릴 이용한 퀴놀론핵과 Heteroaryl Stannes의 결합 -C-7 heteroaryl 퀴놀론 유도체의 합성-

• 영문명: Palladium-Catalyzed Coupling between Quinolone Moieties and Heteroaryl Stannes -Synthesis of C-7 heteroaryl Quinolone Derivatives-
• 발행기관: 대한약학회
• 저자명: 남상훈(Sang Hoon Nam) 함원훈(Won Hun Ham) 김기수(Ki Su Kim) 임태균(Tae Gyun Lim) 양재권(Jae Gwon Yang)
• 간행물 정보: 『약학회지』제37권 제6호 (1993년), 615~620쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.12.30

영문 초록

The cross-coupling reaction of organo tin reagents with a variety of organic halides, catalyzed by palladium, provides a novel method for generating a carbon-carbon bond. We used this method for the antibacterial agents, and synthesis of new quinolone derivatives which have carbon-carbon bond at C-7 position of general quinolone moieties. Aryl tin, quinolone moieties, and palladium catalyst were refluxed in DMF to afford new quinolone derivatives. This palladium catalyzed coupling reactions have capacity for further synthetic elaboration.

키워드

Carbon-carbon bond at C-7 position palladium-catalyzed coupling.