두릅나무 근피 추출물의 약물학적 연구 -흰쥐의 위염 및 위궤양에 대한 효과-

• 영문명: Pharmacological Studies on Root Bark Extract of Aralia elata -Antigastritic and Antiulcerative Effects in Rats-
• 발행기관: 대한약학회
• 저자명: 이은방(Un Bang Lee) 정춘식(Chun Sik Jung)
• 간행물 정보: 『약학회지』제37권 제6호 (1993년), 581~590쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.12.30

영문 초록

In a preliminary screening of the plant extracts for the antigastritic action in rats, the extract of Aralia elata(Araliaceae) showed positive activity in HCl plus ethanol induced gastric lesion. Systematic fractions with hexane, chloroform, ethyl acetate and butanol resulted in the most patent activity with the butanol fraction: This butanol fraction at the oral dose of 200mg/kg exhibited significant inhibition of absolute alcohol induced gastric lesion which was more potent than 100mg/kg of cimetidine and had significant stimulation of mucus secretion. The butanol fraction showed significant decreases in the ulcer indices of Shay ulcers and inhibition of gastric juice secretion with acid output in pylorus-ligated stomachs of rats. It also suppressed the acetic acid induced gastric ulcer. These results might suggest that the butanol fraction had inhibitory action in gastric lesion and ulceration through inhibition of gastric acid secretion and stimulation of mucin secretion in the stomachs of rats.

키워드

Aralia elats root bark butanol fraction gastric lesion gastric ulceration mucin content acetic acid induced ulcer.