돔페리돈의 신장작용

• 영문명: Renal Action of Domperidone in Dog
• 발행기관: 대한약학회
• 저자명: 고석태(Suk Tai Ko) 최홍석(Hong Suk Choi)
• 간행물 정보: 『약학회지』제37권 제6호 (1993년), 561~570쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.12.30

영문 초록

Renal action of domperidone known as dopamine receptor blocker and effect of domperidone on renal function of dopamine were investigated in dog. Domperidone, when administered into vein, produced diuretic action by the improvement of renal hemodynamic state, when given into a renal artery, elicited diuretic action accompanied with natriuresis in only experimental kidney, whereas domperidone given into carotid artery exhibited antidiuretic action by the decrease of Na+ excretion in urine. Diuretic action of dopamine was not influenced by domperidone given into vein or into a renal artery, was blocked by domperidone given into carotid artery. Above results suggest that domperidone produced both peripheral diuretic and central antidiuretic action, and domperidone do not block diuretic action by renal hemodynamic improvement of dopamine in kidney.

키워드

domperidone diuretic and antidiuretic action dog kidney dopamine.