항 AIDS약물 Dioxolane-T와 관련성이 있는 Dioxolane 뉴클레오사이드 합성

• 영문명: Synthesis of Dioxolane-T Related Nucleosides as Potential Anti-HIV Agent
• 발행기관: 대한약학회
• 저자명: 유정만(Jung Man Yoo) 서희경(Hee Kyung Seo) 최보길(Bo Gil Choi) 정병호(Byung Ho Chung) 홍준희(Joon Hee Hong) 천문우(Moon Woo Chun)
• 간행물 정보: 『약학회지』제37권 제6호 (1993년), 591~597쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1993.12.30

영문 초록

Two new 6-azauracil dioxolane nucleosides which are related to Dioxolane T and expected to have anti-HIV activity were asymmetrically synthesized. The key intermediate 8 have been synthesized in ten steps from D-mannose and condensed with 6-azauracil to give 13 and 14 after desilylation, respectively.

키워드

6-azauracil D-mannose 1,6-anhydro-D-mannose dioxolane nucleoside anti-HIV agent (±)-dioxolane-T.