학술논문
68Ga 표지 PET/CT 검사의 최적화된 매개변수에 대한 연구
이용수 0
- 영문명
- Study of 68Ga Labelled PET/CT Scan Parameters Optimization
- 발행기관
- 대한핵의학기술학회
- 저자명
- 곽인석(In Suk Kwak) 이혁(Hyuk Lee) 김시활(Si Hwal Kim) 문승철(Seung Cheol Moon)
- 간행물 정보
- 『핵의학기술』Vol.27 No.2, 111~127쪽, 전체 17쪽
- 주제분류
- 의약학 > 방사선과학
- 파일형태
- 발행일자
- 2023.11.30
4,840원
구매일시로부터 72시간 이내에 다운로드 가능합니다.
이 학술논문 정보는 (주)교보문고와 각 발행기관 사이에 저작물 이용 계약이 체결된 것으로, 교보문고를 통해 제공되고 있습니다.

국문 초록
Purpose: Gallium-68 (68Ga) is increasingly used in nuclear medicine imaging for various conditions such as lymphoma and neuroendocrine tumors by labeling tracers like Prostate Specific Membrane Antigen (PSMA) and DOTA-TOC. However, compared to Fluorine-18 (18F) used in conventional nuclear medicine imaging, 68Ga has lower spatial resolution and relatively higher Signal to Background Ratio (SBR). Therefore, this study aimed to investigate the optimized parameters and reconstruction methods for PET/CT imaging using the 68Ga radiotracer through model-based image evaluation.
Materials and Methods: Based on clinical images of 68Ga-PSMA PET/CT, a NEMA/IEC 2008 PET phantom model was prepared with a Hot vs Background (H/B) ratio of 10:1. Images were acquired for 9 minutes in list mode using DMIDR (GE, Milwaukee WI, USA). Subsequently, reconstructions were performed for 1 to 8 minutes using OS-EM (Ordered Subset Expectation Maximization) + TOF (Time of Flight) + Sharp IR (VPFX-S), and BSREM (Block Sequential Regularized Expectation Maximization) + TOF + Sharp IR (QCFX-S-400), followed by comparative evaluation. Based on the previous experimental results, images were reconstructed for BSREM + TOF + Sharp IR / 2 minutes (QCFX-S-2min) with varying β-strength values from 100 to 700. The image quality was evaluated using AMIDE (freeware, Ver.1.0.1) and Advanced Workstation (GE, USA).
Results: Images reconstructed with QCFX-S-400 showed relatively higher values for SNR (Signal to Noise Ratio), CNR (Contrast to Noise Ratio), count, RC (Recovery Coefficient), and SUV (Standardized Uptake Value) compared to VPFX-S. SNR, CNR, and SUV exhibited the highest values at 2 minutes/bed acquisition time. RC showed the highest values for a 10 mm sphere at 2 minutes/bed acquisition time. For small spheres of 10 mm and 13 mm, an inverse relationship between β-strength increase and count was observed. SNR and CNR peaked at β-strength 400 and then decreased, while SUV and RC exhibited a normal distribution based on sphere size for β-strength values of 400 and above.
Conclusion: Based on the experiments, PET/CT imaging using the 68Ga radiotracer yielded the most favorable quantitative and qualitative results with a 2 minutes/bed acquisition time and BSREM reconstruction, particularly when applying β-strength 400. The application of BSREM can enhance accurate quantification and image quality in 68Ga PET/CT imaging, and an optimization process tailored to each institution's imaging objectives appears necessary.
영문 초록
목차
서론
대상 및 방법
결과
고찰
결론
REFERENCES
키워드
해당간행물 수록 논문
- Study on the PET image quality according to various scintillation detectors based on the Monte Carlo simulation
- Prolactin Monomeric Polyethylene Glycol Measurement Method and Study of Reference Value Verification
- Synthesis of Novel 18F-Labeled-Nitroimidazole-Based Imaging Agents for Hypoxia: Recent Advances
- Calculation of the Least Significant Change Value of Bone Densitometry Using a Dual-Energy X-ray Absorptiometry System
- Femoral Mass in Bone Mineral Densitometry
- L-spine Bone SPECT/CT에서 획득된 저선량 CT 영상을 이용한 용적 골밀도 결과의 유용성
- 68Ga 표지 PET/CT 검사의 최적화된 매개변수에 대한 연구
참고문헌
관련논문
의약학 > 방사선과학분야 BEST
- 민간의료보험 해약 의향 영향 요인: 한국 의료 패널 2019년 2기 자료를 이용하여
- 고준위방사성폐기물 관리와 관련된 사회안전망 구축에 관한 연구
- 임상에서 사용되는 온장고 온도설정 및 한계점에 대한 고찰
의약학 > 방사선과학분야 NEW
- 무증상 치밀 유방 여성에서 인공지능 기반 컴퓨터 보조 진단 장치의 유용성 연구
- 방사선치료 임상실습 환경에 따른 방사선(학)과 학생의 학습 효과 분석
- 딥러닝을 활용한 한국형 유방초음파 영상 정상-종괴 구분 연구
최근 이용한 논문
교보eBook 첫 방문을 환영 합니다!
신규가입 혜택 지급이 완료 되었습니다.
바로 사용 가능한 교보e캐시 1,000원 (유효기간 7일)
지금 바로 교보eBook의 다양한 콘텐츠를 이용해 보세요!
