Synthesis of Novel 18F-Labeled-Nitroimidazole-Based Imaging Agents for Hypoxia: Recent Advances

• 발행기관: 대한핵의학기술학회
• 저자명: Anh Thu Nguyen Hee-Kwon Kim
• 간행물 정보: 『핵의학기술』Vol.27 No.2, 83~93쪽, 전체 11쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2023.11.30

국문 초록

Hypoxia indicates the condition of low oxygen levels in tissues. In oncology, hypoxia can induce cancer progression and metastasis, as well as cause resistance to cancer therapies. The detection of hypoxia by using molecular imaging, particularly, positron emission tomography (PET) has been extensively studied due to many advantages. Nitroimidazoles, the moieties that can be trapped in hypoxic tissues due to selective reduction, have been used to design and synthesize of hypoxia-targeting radiopharmaceuticals. This review provides a summary of synthetic routes towards 18F-labeled-nitroimidazole radiotracers for PET imaging of hypoxia.

목차

Introduction

Development of 18F-labeled radiotracers for hypoxia

Conclusion

REFERENCES

키워드

Hypoxia Radiotracers PET Nitroimidazole Tumor