약용식물의 Peroxynitrite와 Hydroxyl radical 소거 활성

• 영문명: Peroxynitrite and Hydroxyl Radical Scavenging Activity of Medicinal Plants
• 발행기관: 한국자원식물학회
• 저자명: 민오진(Oh Jin Min) 김민석(Min Suk Kim) 곽병희(Byung Hee Kwak) 류동영(Dong Young Rhyu)
• 간행물 정보: 『한국자원식물학회지』제21권 제4호, 254~259쪽, 전체 6쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2008.08.31

영문 초록

The radical scavenging activities of 9 medicinal plants on peroxynitrite (ONOO-) and hydroxyl (∙OH) radical were investigated using in vitro system. The water extracts of 9 medicinal plants showed the protective effect against ONOO- and∙OH radical. In particular, Akebia quinata, Aster scaber, Cudrania tricuspidata, Diospyros kaki, Eriobotrya japonica, Lycium chinense, Parthenocissus tricuspidata and Polygonum aviculare exhibited ONOO-- scavenging activity by about 50% at the concentration of 10μg/ml. Although those ONOO--scavenging activities were lower than that of penicillamine (94.08±3.04%) as a positive control, Eriobotrya japonica (89.87±4.57%) was the most potent scavenger of ONOO- at the concentration of 10μg/ml. Also, Diospyros kaki and Urtica angustifolia showed the strong∙OH-scavenging activity than thiourea, positive control, at the concentration of lmg/ml. Our results indicate that 9medicinal plants may act as free radical scavengers and reduce damages caused by oxidative stress associated with ONOO- and∙OH radical.

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결과 및 고찰

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키워드

Medicinal plant Peroxynitrite Hydroxyl radical Free radical scavenger Oxidative stress