택칠에서 분리한 Corilagin이 Collagen 유발 관절염에 미치는 영향 (Ⅰ)

• 영문명: Studies on the Effect of Corilagin Isolated from Euphorbia helioscopia on Collagen-Induced Arthritis (Ⅰ) - Analysis of Fluorescence Flow Cytometry from Collagen Ⅱ Induced Arthritis Mice Model -
• 발행기관: 한국자원식물학회
• 저자명: 신삼기(Sam Kee Shin) 장준복(Jun Pok Chang) 도은수(Eun Soo Doh)
• 간행물 정보: 『한국자원식물학회지』제21권 제4호, 329~335쪽, 전체 7쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2008.08.31

영문 초록

This study was intended to research into the possibility of corilagin (CRN) isolated from Euphorbia helioscopia as rheumatoid arthritis drug. For the study, CRN was medicated to the abdominal cavity of collagen induced arthritis (CIA) mice that was a animal model for rheumatoid arthritis and its effects on incidence and arthritis index (AI) were studied. The results were as folllows; Medicating corilagin that were isolated from Euphorbia heliscopia to CIA mice resulted in inhibiting an incidence of arthritis and reducing in arthritis index. It was found that inflammatory cells were remarkably decreased and joint cavity was well secured. Also it was displayed that the formation of pannus was not observed and a cartilage was preserved well by cell histological research. Performing fluorescence flow cytometry of CIA mice resulted in reducing in inflammatory cells infiltrated each tissue.

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Corilagin Collagen induce arthritis mice Arthritis Fluorescence flow cytometry Inflammatory cells