약시안에서 아트로핀 처벌치료의 약리 효과

• 영문명: Pharmacologic Effects of Atropine Penalization in Amblyopic Eyes
• 발행기관: 대한안과학회
• 저자명: 박선호 박새미 조아란 박성희,Sun Ho Park, MD, Sae Mi Park, MD, A Ran Cho, MD, Song Hee Park, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number4, 590~595쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.04.15

영문 초록

Purpose: To analyze the pharmacologic effect of atropine penalization in amblyopic eyes. Methods: Distant and near visual acuity, near point of accommodation (NPA), and pupil size were measured in the sound eye of 40 children with amblyopia before and after receiving atropine sulfate 1% solution. Amblyopic children were divided into 2 groups according to the time of follow-up visit: 4-days and 7-days after injection; the same tests were performed on all the scheduled follow- up visits. This study included a control group of 20 normal children who received the same test on the initial visit and the scheduled follow-up visits. Results: Visual acuity of the sound eye at distance showed greater decreases in children with 4-day follow-up visits compared with 7-day visits in the amblyopic group (p = 0.24). There was no significant difference in near visual acuity between the amblyopic group and the normal control group by follow-up interval (p = 0.98, p = 0.75). Near point of accommodation significantly increased in the 4-day visit group in both the amblyopic and the normal control groups (p = 0.04 and p = 0.03, respectively), Pupil size was significantly maintained in the 4-day visit, amblyopic group (p = 0.01). Conclusions: Atropine effectively decreased the vision of the sound eye in amblyopic children. However, to maintain the pharmacologic effect, two separate atropine instillations per week (on a weekday and the weekend) should be considered as a treatment for amblyopia. J Korean Ophthalmol Soc 2014;55(4):590-595

키워드

Amblyopia, Atropine penalization treatment, Weekend atropine