안구표면 편평상피세포 암종의 임상양상과 예후 인자에 대한 분석

• 영문명: Analysis of Clinical Features and Prognostic Factors of Ocular Surface Squamous Neoplasia
• 발행기관: 대한안과학회
• 저자명: 정현호 양지명 윤경철,Hyun Ho Jung, MD, Jee Myung Yang, MD, Kyung Chul Yoon, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number4, 506~512쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.04.15

영문 초록

Purpose: To analyze the clinical features and prognostic factors of ocular surface squamous neoplasia (OSSN). Methods: A total of 31 eyes of 31 patients with suspected OSSN who were treated with excision and biopsy were retrospectively reviewed. Clinical features such as patient symptoms, invasion type, morphologic feature and size of lesion were analyzed. All patients were treated with simple excision or mitomycin C combination therapy. Factors affecting recurrence were evaluated. Results: The most common symptom, invasion type, morphological feature, lesion size and histological diagnosis were foreign body sensation (38.7%), combined conjunctiva and cornea type (71.0%), gelatinous type (74.2%), 5 - 10 mm in largest diameter (45.2%) and intraepithelial neoplasia (51.6%), respectively. Age, sex, morphological features, lesion size and histological diagnosis had no effect on recurrence. Mitomycin C combination therapy was significantly associated with decreased recurrence compared to simple excision (p < 0.05). Conclusions: In OSSN, intraepithelial neoplasia was the most common subtype. Mitomycin C combination therapy was effective in decreasing recurrence. J Korean Ophthalmol Soc 2014;55(4):506-512

키워드

Mitomycin C, Ocular surface squamous neoplasia