데모덱스 안검염 환자에서 폴리헥사메틸렌 비구아니드를 이용한 안검 세척의 치료효과

• 영문명: Clinical Efficacy of Polyhexamethylene Biguanide Lid Scrub on Demodex Blepharitis
• 발행기관: 대한안과학회
• 저자명: 문준형 김재찬,Jun Hyung Moon, MD, Jae Chan Kim, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume55,number4, 493~497쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2014.04.15

영문 초록

Purpose: To evaluate the treatment efficacy of polyhexamethylene biguanide (PHMB) lid scrub on Demodex blepharitis. Methods: Thirty-one patients diagnosed with Demodex blepharitis were evaluated every 2 weeks during 8 weeks of lid scrub treatment with 0.4% PHMB. Patients underwent epilation of 4 eyelashes in each eye, and the number of Demodex lesions was counted. The patients answered questionnaires regarding ocular surface discomfort and underwent ophthalmologic exams including slit lamp and tear breakup time (TBUT). Compliance was recorded as 1 of 3 stages (good, moderate, poor). Results: One patient was excluded for poor compliance. After PHMB lid scrub for 8 weeks, Demodex count was reduced in 28 of 30 patients (pre-PHMB 7.9 ± 3.6 counts, post-PHMB 2.2 ± 2.4 counts, p < 0.01). In addition, TBUT showed a statistically significant increase after PHMB lid scrub (pre-PHMB 2.7 ± 0.8 seconds, post-PHMB 3.4 ± 0.9 seconds, p < 0.01). Ocular surface disease index (OSDI) score was reduced in 28 of 30 patients (pre-PHMB 22.0 ± 10.7 points, post-PHMB 7.4 ± 6.0 points, p < 0.01). Conclusions: Eight weeks of treatment with polyhexamethylene biguanide lid scrub on Demodex blepharitis had good treatment efficacy for reducing Demodex counts and OSDI scores and increasing TBUT. J Korean Ophthalmol Soc 2014;55(4):493-497

키워드

Demodex blepharitis, Polyhexamethylene biguanide