정상안압녹내장의 시야손상 진행과 각막생체역학인자의 관련성

• 영문명: The Association Between Corneal Biomechanical Properties and Progression of Visual Field Loss in Normal Tension Glaucoma
• 발행기관: 대한안과학회
• 저자명: 박종혁 최규룡,Jong Hyuk Park, MD, Kyu-Ryong Choi, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number11, 1757~1766쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.11.15

영문 초록

Purpose: To evaluate the association between corneal biomechanical properties and progression of visual field loss in normal tension glaucoma. Methods: This study enrolled 73 eyes of 73 patients with normal tension glaucoma who were undergoing medical treatment, and classified them into progressing and nonprogressing groups by visual field trend analysis. The corneal biomechanical properties measured by the Ocular Response Analyzer (ORA; Reichert Instruments, Depew, NY, USA), central corneal thickness, and Goldmann applanation tonometry were comparatively analyzed between the 2 groups. Results: Twenty-six eyes reached a progression endpoint. The prevalence of hypertension was higher in the progressing group (42.3%, progressing, 17.0%, nonprogressing; p = 0.03). Progressing eyes had lower corneal hysteresis (9.1 ± 1.3 vs. 9.8 ± 1.5 mm Hg, p = 0.03) and lower corneal resistance factor (9.5 ± 1.5 vs. 10.4 ± 1.4 mm Hg, p = 0.01) compared with nonprogressing eyes. Upon multivariate analysis, the presence of hypertension (odds ratio [OR] = 3.46, p = 0.03) and corneal hysteresis (CH) (OR = 0.66 per mm Hg lower, p = 0.02) remained statistically significant. Conclusions: The CH measurement with ORA was significantly associated with risk of visual field progression in normal tension glaucoma. Eyes with lower CH had a greater risk of progression of visual field loss than those with higher CH. J Korean Ophthalmol Soc 2013;54(11):1757-1766

키워드

Corneal biomechanical properties, Corneal hysteresis, Normal tension glaucoma, Ocular Response Analyzer, Progression