절반용량의 광역학치료를 받은 만성 중심장액맥락망막병증에서 스펙트럼영역 빛간섭단층촬영 소견과 시력과의 상관관계

• 영문명: Correlation Between Optical Coherence Tomography and Visual-Acuity in Chronic Central Serous Chorioretinopathy Treated with Half Dose Photodynamic Therapy
• 발행기관: 대한안과학회
• 저자명: 박시윤 고형준 김용민,Si Yoon Park, MD, Hyung Jun Koh, MD, PhD, Yong Min Kim, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number11, 1715~1722쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.11.15

영문 초록

Purpose: To evaluate the results of half-dose photodynamic therapy (PDT) and determine the correlation between morphological changes measured by spectral-domain optical coherence tomography (SD-OCT) and visual acuity in patients with chronic central serous chorioretinopathy (CSC). Methods: Twenty-five eyes of 25 patients with chronic CSC who had received half-dose verteporfin PDT were enrolled in the present study. The best-corrected visual acuity (BCVA), outer nuclear layer (ONL) thickness, and the integrity of the photoreceptor inner and outer segment junction (IS/OS) using SD-OCT were evaluated at baseline and at 3 and 6 months after treatment. Results: The neurosensory retinal detachment disappeared in all eyes 6 months after treatment. The BCVA improved significantly from 0.50 ± 0.32 to 0.31 ± 0.29 log MAR at 6 months (p < 0.001). The average ONL thickness at the central fovea was 88.76 ± 19.95 μm at 6 months and the ONL thickness was well correlated with the BCVA (γ = -0.64; p = 0.001). There was no significant correlation between the status of IS/OS and the BCVA. Conclusions: Half-dose PDT is effective in treating chronic CSC resulting in visual improvement and complete resolution of neurosensory retinal detachment. The ONL thickness which was positively correlated with the BCVA could be an indicator for visual prognosis of chronic CSC. J Korean Ophthalmol Soc 2013;54(11):1715-1722

키워드

Chronic central serous chorioretinopathy, Half-dose photodynamic therapy, Spectral domain optical coherence tomography