전층각막이식술 후 각막감각의 장기 변화 및 이와 관련된 눈물막변수의 분석

• 영문명: Analysis of Long-Term Change in Corneal Sensitivity after Penetrating Keratoplasty and Associated Tear Film Parameters
• 발행기관: 대한안과학회
• 저자명: 정세형 오한진 윤경철,Se Hyeong Jeong, MD, Han Jin Oh, MD, Kyung Chul Yoon, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume53,number9, 1247~1253쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.09.15

영문 초록

Purpose: To evaluate the long-term changes in the corneal sensitivity and to analyze which tear film parameters correlate with corneal sensitivity after penetrating keratoplasty (PKP). Methods: Twenty-eight eyes of 28 patients who underwent PKP were included in the present study. Corneal sensitivity, Schirmer test, tear break-up time, tear clearance rate, and keratoepitheliopathy were evaluated at 1, 3, 6, 12, and 24 months postoperatively. Then, which tear film parameters correlated with corneal sensitivity during the follow-up period were analyzed. Results: Corneal sensitivity was 5.18 ± 3.96 mm at one month postoperatively and increased to 29.64 ± 12.39 mm (p < 0.05) at 24 months postoperatively but was still not in the normal range. Tear break-up time and keratoepitheliopathy improved at postoperative three months and six months, respectively, compared with one month postoperatively, and both measures normalized at 24 months postoperatively. Schirmer test results and tear clearance rate were in the normal range during the follow-up period. Corneal sensitivity was correlated with tear break-up time from three to 24 months postoperative and with tear clearance rate from one month to 24 months postoperative (p < 0.05). Conclusions: Change in corneal sensitivity after penetrating keratoplasty correlates with tear break-up time and tear clearance rate; therefore, tear break-up time and tear clearance rate can be used as parameters for management of dry eye after PKP. J Korean Ophthalmol Soc 2012;53(9):1247-1253

키워드

Corneal sensitivity, Penetrating keratoplasty, Tear film