신생혈관녹내장에서 항대사제의 병용 여부에 따른 아메드 장치 삽입술의 수술 성공률 비교

• 영문명: Ahmed Valve Implantation with Adjunctive Mitomycin C and 5-Fluorouracil: Outcomes at 2 Years
• 발행기관: 대한안과학회
• 저자명: 임성협 서원문 박준정 윤성욱,Sung Hyup Lim, MD, Won Moon Seo, MD, Jun-Jeong Park, MD, Seong Uk Yun, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume52,number12, 1470~1477쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.12.15

영문 초록

Purpose: To evaluate the outcomes of Ahmed valve implantation in neovascular glaucoma patients who received intraoperative mitomycin C (MMC) and postoperative 5-fluorouracil (5-FU) after 24 months of follow-up. Methods: A total of 40 eyes from 40 patients with neovascular glaucoma who received antiglaucomatous medication without previous glaucoma surgery were included in the present study. The patients were divided into 2 groups. The control group (20 eyes) underwent Ahmed valve implantation only and the study group (20 eyes) underwent Ahmed valve implantation and received intraoperative MMC and postoperative 5-FU. Failure was defined as the first occurrence of any of the following: 1) the first of 3 consecutive visits where intraocular pressure (IOP) was over 18 mmHg; 2) 20% IOP reduction from baseline; 3) the final number of topical medications was not reduced by at least two from baseline; 4) the need for additional surgery; or 5) the occurrence of a serious complication. Results: In the control group, the cumulative success rate was 19.1% at 24 months. The cumulative success rate in the study group was 43.7% at 24 months. Serious complications such as endophthalmitis, valve exposure, or prolonged hypotony were not observed. Conclusions: The adjunctive use of intraoperative MMC and postoperative 5-FU with Ahmed valve implantation resulted in a high success rate and good IOP control and did not cause serious complications during the follow-up period. J Korean Ophthalmol Soc 2011;52(12):1470-1477

키워드

Ahmed valve implantation, Neovascular glaucoma, Success rate, MMC, 5-FU