이마티니브 메실레이트에 의한 수정체상피세포의 섬유아세포로의 전환분화억제효과

• 영문명: Inhibitory Effects of Imatinib Mesylate on Transdifferentiation of Lens Epithelial Cells into Fibroblast
• 발행기관: 대한안과학회
• 저자명: 박태성 태준석 박세민 오중협,Tea Sung Park, M.D., Jun Seok Tea, M.D., Seh Min Park, M.D., Jung Hyub Oh, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume46,number2, 257~270쪽, 전체 14쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.02.28

영문 초록

Purpose: To investigate whether Imatinib mesylate (IM) could inhibit the transdifferentiation of the lens epithelial cells (LECs) into fibroblasts using the capsular bag model. Methods: In the capsular bag model, LECs were cultured by exposure to IM at various concentrations for 3 min. The effect of IM was analysed by observing the covering area, numbers of α-SMA positive cell, and BrdU incorporated proliferating cells. The same analysis was performed in the culture of LECs with TGF-β. Results: The covering area was significantly decreased by the treatment of 30 ?M IM, and the positive cells for α-SMA and BrdU were also decreased by IM treatment in a dose dependent manner. In addition, increasing TGF-β concentration accelerated transdifferentiation, but suppressed the acceleration of the transdifferentiation induced by TGF-β. Conclusions: In the capsular bag model, IM effectively inhibited not only the transdifferentiation of LECs into fibroblasts but also the TGF-β induced acceleration of the transdifferentiation.

키워드

α-Smooth muscle actin, Capsular bag model, Fibroblast, Imatinib mesylate, Transdifferentiation