beta-락탐계 항생물질의 폴리아크릴산 중합체의 합성 및 항균성

• 영문명: Synthesis and Antibiotic Activities of Poly(acrylic acid) Modified beta-Lactam Cyclics
• 발행기관: 대한약학회
• 저자명: 진정일(Jung Il Jin) 최성모(Sung Mo Choi) 장민선(Min Sun Chang) 민신홍(Shin Hong Min)
• 간행물 정보: 『약학회지』제30권 제5호 (1986년), 232~238쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1986.10.30

영문 초록

A series of modified poly(acrylic acid)''s containing different levels of 6-aminopenicillanic acid (6-APA), 7-aminocephalosporanic acid (7-ACA) and 6-[D-(-)-alpha-aminophenyl acetamido]penicillanic acid (ampicillin) as pendant groups were prepared. Antibiotic activities of the newly prepared drugs were examined against the various gram-positive and gram-negative bacteria. It was found that ampicillin modified composition posses antibiotic activities against the gram-negative as well as the gram-positive bacteria.