수용액중 미녹시딜의 안정성

• 영문명: Stability of Minoxidil in Aqueous Solution
• 발행기관: 대한약학회
• 저자명: 김길수(Kil Soo Kim)
• 간행물 정보: 『약학회지』제30권 제5호 (1986년), 228~231쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1986.10.30

영문 초록

The effect of temperature and pH on the degradation of minoxidil in the aqueous solution was investigated and the stability of pharmaceutical preparation for solution was also studied. The degradation of minoxidil in the aqueous solution was first order type reaction and the rate constant at 20oC in pH 7.0 phosphate buffer solution was 9.464 X 10-3day-1 and calculated activation energy was 11.7kcal/mol. The degradation of minoxidil was acid-base catalytic reaction and the most stable range of pH was about 5.0. The liquid pharmaceutical preparation was very stable in 3 months.