리팜피신과 이소니아짓의 약물상호작용

• 영문명: Drug Interaction of Rifampicin and Isoniazid
• 발행기관: 대한약학회
• 저자명: 범진필(Jin Pil Burm) 최준식(Jun Shik Choi)
• 간행물 정보: 『약학회지』제30권 제5호 (1986년), 208~213쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1986.10.30

영문 초록

Rifampicin suspension was administered orally at a does of 34mg/kg to six rabbits after 5, 10 and 20mg/kg pretreatment of isoniazid twice daily for 9 days. The blood level of rifampicin was decreased significantly by isoniazid 10mg/kg, 20mg/kg pretreatment. The renal clearance(CLr) of rifampicin was increased by isoniazid 20mg/kg and the biliary clearance(CLb) was increased by isoniazid 10mg/kg and 20mg/kg pretreatment. Elimination rate constant(K) and time to reach maximum concentration(tmax) were increased by isoniazid pretreatment. But half-life and maximum concentration(Cmax) were decreased. Relative bioavailability was decreased significantly by isoniazid 10mg/kg and 20mg/kg pretreatment.