Caerulein의 흰쥐 취외분비반응에 미치는 phenoxybenzamine의 영향

• 영문명: Effects of Phenoxybenzamine on Pancreatic Amylase Secretory Response to Caerulein
• 발행기관: 대한약리학회
• 저자명: 김혜영(H.Y. Kim) 노재열(J.Y Ro) 조태순(T.S. Cho) 홍사석(S.S. Hong)
• 간행물 정보: 『대한약리학잡지』제12권 제2호, 7~12쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1976.12.31

영문 초록

A portion of duodenum laid pancreatic duct opening were perfused continuously with physiological saline under urethane anesthesia in rats. The pancreatic amylase secretory response to caerulein was studied with autonomic blockers, such as phenoxybenzamine, dibenamine, phentolamine, hexamethonium, propranolol, atropine, and cyproheptadine. The pancreatic amylase output to caerulein, 7.5ng/kg i.v., was markedly increased and the value was approximately three times greater than control. The caerulein-stimulated pancreatic amylase secretion was significantly decreased by i.v. phenoxybenzamine and propranolol treatment, but not by phentolamine or dibenamine. Secretory response of pancreatic amylase to caerulein was not affected by i.v. atropine, hexamethonium or cyproheptadine. These result lead to the conclusion that phenoxybenzamine may inherently inhibit the secretory response of pancreatic amylase to caerulein, and this effect was not related with α-adrenergic receptor blocking action.