Angiotensin-Converting Enzyme Gene Polymorphism is not Associated with Myocardial Infarction in Koreans
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- 영문명
- Angiotensin-Converting Enzyme Gene Polymorphism is not Associated with Myocardial Infarction in Koreans
- 발행기관
- 대한생리학회-대한약리학회
- 저자명
- Seok Chai Dong-Ryul Sohn
- 간행물 정보
- 『The Korean Journal of Physiology & Pharmacology』제2권 제5호, 645~650쪽, 전체 6쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 1998.01.01
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국문 초록
영문 초록
To assess the relationship between angiotensin-converting enzyme (ACE) gene polymorphism and myocardial infarction in Koreans, we recruited 112 healthy, unrelated subjects (mean age 53.4 years) and 104 myocardial infarction survivors (mean age 54.2 years) of both sexes. An insertion/deletion (I/D) polymorphism of the ACE gene was typed by polymerase chain reaction. The I allelic frequency of ACE gene in Korean subjects was irrelavant to myocardial infarction (patients, 65%; control subjects 66%), as was true with the D allele. When compared with other populations, the frequency of D allele in Koreans (0.34) was lower than that in Caucasians, and was close to that of other Oriental populations. The data suggest that the ACE gene polymorphism is not an independent genetic risk factor for myocardial infarction in Koreans.
목차
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