Dual Action of d-Tubocurarine on Large-Conductance Ca2+-activated K+ Channels from Rat Brain Reconstituted into Planar Lipid Bilayer

• 영문명: Dual Action of d-Tubocurarine on Large-Conductance Ca²⁺-activated K⁺ Channels from Rat Brain Reconstituted into Planar Lipid Bilayer
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Sungkwon Chung Jung Hoon Shin
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제2권 제5호, 549~553쪽, 전체 5쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1998.01.01

영문 초록

Using the planar lipid bilayer method, we investigated the effect of d-tubocurarine (dTC) on the extracellular side of large-conductance Ca²⁺-activated K⁺ channel from rat brain. When the initial open probability (Po) of the channel was relatively high, dTC decreased channel activity in a concentration dependent manner. In contrast, when the initial Po was lower, sub-micro molar dTC increased channel activity by destabilizing the closed states of the channel. Further addition of dTC up to micro molar range decreased channel activity. This dual effect of dTC implicates that there exist at least two different binding sites for dTC.

키워드

Ca²⁺-activated K⁺ Channel d-Tubocurarine Planar lipid bilayer