Neural Adaptation of Beta Adrenergic Receptor Subtypes after Chronic Imipramine Treatment A Quantitative Autoradiographic Study

• 영문명: Neural Adaptation of Beta Adrenergic Receptor Subtypes after Chronic Imipramine Treatment A Quantitative Autoradiographic Study
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Hae-Young Park Young-Sook Hong Chan-Woong Park
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제1권 제2호, 161~167쪽, 전체 7쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1997.01.01

영문 초록

This study compares the subtypes of central beta adrenergic receptors (ARs) of brains of untreated rats with those of imipramine-treated rats. Beta adrenergic receptors were measured by quantitative autoradiography of the binding of ³H-dihydroalprenolol (³H-DHA) in coronal sections of rat brain. Repeated treatment of rats with imipramine significantly reduced the binding of ³H-DHA to beta-1 AR in many brain areas, especially throughout the cerebral cortex, hippocampus, thalamus, and amygdala. Significant reductions of the binding of ³H-DHA to beta-2 AR were not found in any area of the brain. These data suggests that a selective down-regulation of beta-1 AR may be involved in the adaptive changes occurring after prolonged imipramine treatment.

키워드

Beta adrenergic receptor Rat brain Autoradiography Imipramine